作者
Tamirat Gebru Woldearegai, Peter G Kremsner, Jürgen FJ Kun, Benjamin Mordmüller
发表日期
2013/5/1
期刊
Transactions of the Royal Society of Tropical Medicine and Hygiene
卷号
107
期号
5
页码范围
328-331
出版商
Oxford University Press
简介
Background
This study was conducted to estimate the prevalence of Plasmodium vivax and polymorphisms in the Duffy antigen receptor for chemokines (DARC) gene in patients with suspected malaria from eastern (Harar) and southwestern (Jimma) Ethiopia.
Methods
Plasmodium presence and species was assessed by microscopy in 1304 and 627 febrile patients in Harar and Jimma, respectively, during October–November 2009. All microscopy-positive samples were confirmed by PCR. DARC gene polymorphisms were identified by DNA sequencing.
Results
Plasmodium vivax was the dominant species in Harar (74/98, 76%) and P. falciparum was more common in Jimma (70/107, 65%). We found 17/98 (17%) and 24/107 (22%) homozygous Duffy-negative patients in Harar and Jimma, respectively. Unexpectedly, three Duffy-negative …
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TG Woldearegai, PG Kremsner, JFJ Kun, B Mordmüller - Transactions of the Royal Society of Tropical Medicine …, 2013