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Introduction: VGF (non-acronymic) is a neurosecretory protein implicated in neuroplasticity associated with depression, learning, memory, and chronic pain. We previously demonstrated that VGF-derived peptides are involved in the establishment of hypersensitivity in mouse models of chronic pain. We have also shown that the peptide TLQP-62 potentiates calcium responses to glutamate (Glu) in a subset of spinal neurons in naïve male mice. Studies in the hippocampus have suggested that the actions of TLQP-62 are mediated in part by BDNF/TrkB signaling, and in spinal dorsal horn BDNF/TrkB signaling has been shown to participate in neuroplasticity mediated by the NMDA receptor (NMDAR) subunit GluN2B. This study aims to determine the mechanism of the spinal effects of TLQP-62. We hypothesized that the potentiation of spinal Glu responses by TLQP-62 requires …