作者
Florence TH Wu, Marianne O Stefanini, Feilim Mac Gabhann, Christopher D Kontos, Brian H Annex, Aleksander S Popel
发表日期
2010/3
来源
Journal of cellular and molecular medicine
卷号
14
期号
3
页码范围
528-552
出版商
Blackwell Publishing Ltd
简介
- • Introduction
- ‐ Angiogenesis in physiology and pathology
- ‐ Angiogenesis in current medicine
- ‐ VEGF ligand and receptor system: where does sVEGFR1 fit?
- ‐ Ligands: the human VEGF family
- ‐ Membrane‐bound signalling receptors: VEGFRs
- ‐ Non‐signalling co‐receptors and matrix proteins: HSPGs and NRPs
- ‐ Soluble receptors: sVEGFR1, sVEGFR2, sNRP1
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- ‐
- • Molecular biology of sVEGFR1
- • Physiological and pathophysiological roles of sVEGFR1
- • Molecular mechanism of sVEGFR1’s anti‐angiogenic potential
- • sVEGFR1 as a clinical marker for disease
- • Plasma VEGF and sVEGFR1: non‐uniform predictors of angiogenic status across all diseases
- • Systems biology perspective: unifying interpretation of plasma angiogenic markers
- ‐ Baseline heterogeneity in clinical measurements of healthy VEGF and sVEGFR1 levels in plasma
- ‐ Effect of sVEGFR1 on VEGF …
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FTH Wu, MO Stefanini, FM Gabhann, CD Kontos… - Journal of cellular and molecular medicine, 2010