作者
Jose A Diaz, Andrea T Obi, Daniel D Myers Jr, Shirley K Wrobleski, Peter K Henke, Nigel Mackman, Thomas W Wakefield
发表日期
2012/3
来源
Arteriosclerosis, thrombosis, and vascular biology
卷号
32
期号
3
页码范围
556-562
出版商
Lippincott Williams & Wilkins
简介
Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute to our understanding of the initiation, propagation, and resolution of venous thrombus, as well as allow for the evaluation of new pharmaceutical approaches to prophylaxis and treatment of deep vein thrombosis. In this work we review the ferric chloride model, the inferior vena cava ligation model, the inferior vena cava stenosis models, and the electrolytic inferior vena cava model and compare their advantages and disadvantages.
学术搜索中的文章
JA Diaz, AT Obi, DD Myers Jr, SK Wrobleski, PK Henke… - Arteriosclerosis, thrombosis, and vascular biology, 2012