作者
Soracha E Ward, Helen Fogarty, Ellie Karampini, Michelle Lavin, Sonja Schneppenheim, Rita Dittmer, Hannah Morrin, Siobhan Glavey, Cliona Ni Cheallaigh, Colm Bergin, Ignacio Martin‐Loeches, Patrick W Mallon, Gerard F Curley, Ross I Baker, Ulrich Budde, Jamie M O’Sullivan, James S O’Donnell, Irish COVID‐19 Vasculopathy Study (iCVS) investigators, Niamh O’Connell, Mary Byrne, Liam Townsend, Natalie L McEvoy, Jennifer Clarke, Maria Boylan, Razi Alalqam, Amy P Worrall, Claire Kelly, Eoghan de Barra, Roger Preston, Dermot Kenny
发表日期
2021/8
期刊
Journal of Thrombosis and Haemostasis
卷号
19
期号
8
页码范围
1914-1921
简介
Background
Consistent with fulminant endothelial cell activation, elevated plasma von Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19. The multimeric size and function of VWF are normally regulated through A Disintegrin And Metalloprotease with ThrombSpondin Motif type 1 motif, member 13 (ADAMTS‐13)‐‐mediated proteolysis.
Objectives
This study investigated the hypothesis that ADAMTS‐13 regulation of VWF multimer distribution may be impaired in severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2) infection contributing to the observed microvascular thrombosis.
Patients and Methods
Patients with COVID‐19 (n = 23) were recruited from the Beaumont Hospital Intensive Care Unit (ICU) in Dublin. Plasma VWF antigen, multimer distribution, ADAMTS‐13 activity, and known inhibitors thereof were assessed.
Results
We observed markedly increased …
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SE Ward, H Fogarty, E Karampini, M Lavin… - Journal of Thrombosis and Haemostasis, 2021