作者
Kai Sun, Ingrid Wernstedt Asterholm, Christine M Kusminski, Ana Carolina Bueno, Zhao V Wang, Jeffrey W Pollard, Rolf A Brekken, Philipp E Scherer
发表日期
2012/4/10
期刊
Science Signalling
卷号
109
期号
15
页码范围
5874
出版商
AAAS
简介
Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis, inflammation, and ultimately insulin resistance. We hypothesized that VEGF-A–induced stimulation of angiogenesis enables sustained and sufficient oxygen and nutrient exchange during fat mass expansion, thereby improving adipose tissue function. Using a doxycycline (Dox)-inducible adipocyte-specific VEGF-A overexpression model, we demonstrate that the local up-regulation of VEGF-A in adipocytes improves vascularization and causes a “browning” of white adipose tissue (AT), with massive up-regulation of UCP1 and PGC1α. This is associated with an increase in energy expenditure and resistance to high fat diet-mediated metabolic insults. Similarly, inhibition of VEGF-A–induced activation of VEGFR2 during the early phase of high fat diet-induced weight gain, causes aggravated systemic insulin resistance …
学术搜索中的文章
K Sun, IW Asterholm, CM Kusminski, AC Bueno… - Proceedings of the national academy of sciences, 2012