作者
Lorenz Kuessel, Heinrich Husslein, Eliana Montanari, Michael Kundi, Gottfried Himmler, Julia Binder, Judith Schiefer, Harald Zeisler
发表日期
2019/12/18
期刊
Clinical Chemistry and Laboratory Medicine (CCLM)
卷号
58
期号
1
页码范围
50-58
出版商
De Gruyter
简介
Background
We investigated the dynamics and the predictive value of soluble syndecan-1 (Sdc-1), a biomarker of endothelial dysfunction, in uneventful pregnancies and pregnancies complicated by preeclampsia (PE).
Methods
Serum levels of Sdc-1 were measured at sequential time points during and after uneventful pregnancies (control, n = 95) and pregnancies developing PE (PE_long, n = 12). Levels were further measured in women with symptomatic PE (PE_state, n = 46) at a single time point.
Results
Sdc-1 levels increased consistently throughout pregnancy. In the PE_long group Sdc-1 levels were lower at all visits throughout pregnancy, and reached significance in weeks 18–22 (p = 0.019), 23–27 (p = 0.009), 28–32 (p = 0.006) and 33–36 (p = 0.008). After delivery, Sdc-1 levels dropped sharply in all pregnancies but were significantly elevated in the PE_long group. The predictive power …
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L Kuessel, H Husslein, E Montanari, M Kundi… - Clinical Chemistry and Laboratory Medicine (CCLM), 2019