作者
Wenchuan Wu, Jin He, John L Cameron, Martin Makary, Kevin Soares, Nita Ahuja, Neda Rezaee, Joseph Herman, Lei Zheng, Daniel Laheru, Michael A Choti, Ralph H Hruban, Timothy M Pawlik, Christopher L Wolfgang, Matthew J Weiss
发表日期
2014/9
期刊
Annals of surgical oncology
卷号
21
页码范围
2873-2881
出版商
Springer US
简介
Background
The impact of postoperative complications on the administration of adjuvant therapy following pancreaticoduodenectomy (PD) for adenocarcinoma is still unclear.
Methods
A retrospective review of all patients undergoing PD at our institution between 1995 and 2011 was performed. Clinicopathological data, including Clavien–Dindo complication grade, time to adjuvant therapy (TTA), and survival, were analyzed.
Results
A total of 1,144 patients underwent PD for adenocarcinoma between 1995 and 2011. The overall complication rate was 49.1 % and clinically severe complications (≥IIIb) occurred in 4.2 %. Overall, 621 patients (54.3 %) were known to have received adjuvant therapy. The median TTA was 60 days. Although the presence of a complication was associated with a delay in TTA (p = 0.002), the …
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W Wu, J He, JL Cameron, M Makary, K Soares… - Annals of surgical oncology, 2014