作者
Georgios Gemenetzis, Vincent P Groot, Alex B Blair, Daniel A Laheru, Lei Zheng, Amol K Narang, Elliot K Fishman, Ralph H Hruban, Jun Yu, Richard A Burkhart, John L Cameron, Matthew J Weiss, Christopher L Wolfgang, Jin He
发表日期
2019/8/1
期刊
Annals of surgery
卷号
270
期号
2
页码范围
340-347
出版商
LWW
简介
Objective:
The aim of the study was to identify the survival of patients with locally advanced pancreatic cancer (LAPC) and assess the effect of surgical resection after neoadjuvant therapy on patient outcomes.
Background:
An increasing number of LAPC patients who respond favorably to neoadjuvant therapy undergo surgical resection. The impact of surgery on patient survival is largely unknown.
Materials and Methods:
All LAPC patients who presented to the institutional pancreatic multidisciplinary clinic (PMDC) from January 2013 to September 2017 were included in the study. Demographics and clinical data on neoadjuvant treatment and surgical resection were documented. Primary tumor resection rates after neoadjuvant therapy and overall survival (OS) were the primary study endpoints.
Results:
A total of 415 LAPC patients were included in the study. Stratification of neoadjuvant therapy in FOLFIRINOX-based …
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G Gemenetzis, VP Groot, AB Blair, DA Laheru, L Zheng… - Annals of surgery, 2019