作者
Vincent P Groot, Georgios Gemenetzis, Alex B Blair, Roberto J Rivero-Soto, Jun Yu, Ammar A Javed, Richard A Burkhart, Inne HM Borel Rinkes, I Quintus Molenaar, John L Cameron, Matthew J Weiss, Christopher L Wolfgang, Jin He
发表日期
2019/6/1
期刊
Annals of surgery
卷号
269
期号
6
页码范围
1154-1162
出版商
LWW
简介
Objectives:
To establish an evidence-based cut-off to differentiate between early and late recurrence and to compare clinicopathologic risk factors between the two groups.
Summary Background Data:
A clear definition of “early recurrence” after pancreatic ductal adenocarcinoma resection is currently lacking.
Methods:
Patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma between 2000 and 2013 were included. Exclusion criteria were neoadjuvant therapy and incomplete follow-up. A minimum P-value approach was used to evaluate the optimal cut-off value of recurrence-free survival to divide the patients into early and late recurrence cohorts based on subsequent prognosis. Potential risk factors for early recurrence were assessed with logistic regression models.
Results:
Of 957 included patients, 204 (21.3%) were recurrence-free at last follow-up. The optimal length of recurrence-free survival to …
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VP Groot, G Gemenetzis, AB Blair, RJ Rivero-Soto… - Annals of surgery, 2019