作者
Israel Molina, Milena S Marcolino, Magda C Pires, Lucas Emanuel F Ramos, Rafael T Silva, Milton H Guimarães, Isaias José R. de Oliveira, Rafael LR Carvalho, Aline Gabrielle S. Nunes, Ana Lara RM de Barros, Ana Luiza BA Scotton, Angélica Aparecida C. Madureira, Bárbara L. Farace, Cíntia A de Carvalho, Fernanda D A Rodrigues, Fernando Anschau, Fernando A Botoni, Guilherme F Nascimento, Helena Duani, Henrique C Guimarães, Joice C de Alvarenga, Leila B Moreira, Liege B Zandoná, Luana F de Almeida, Luana M Oliveira, Luciane Kopittke, Luís C. Castro, Luisa Elem A Santos, Máderson AS Cabral, Maria Angélica P. Ferreira, Natália CS Sampaio, Neimy R de Oliveira, Saionara C Francisco, Sofia JTS Lopes, Tatiani O Fereguetti, Veridiana B dos Santos, Victor Eliel B de Carvalho, Yuri C Ramires, Antonio Luiz P Ribeiro, Freddy Antonio B Moscoso, Rogério Moura, Carisi A Polanczyk, Maria do Carmo P Nunes
发表日期
2021/3/26
期刊
medRxiv
页码范围
2021.03. 22.21254078
出版商
Cold Spring Harbor Laboratory Press
简介
Objective
Chagas disease (CD) continues to be a major public health burden in Latina America, where co-infection with SARS-CoV-2 can occur. However, information on the interplay between COVID-19 and Chagas disease is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients.
Methods
Patients with COVID-19 diagnosis were selected from the Brazilian COVID-19 Registry, a prospective multicenter cohort, from March to September, 2020. CD diagnosis was based on hospital record at the time of admission. Study data were collected by trained hospital staff using Research Electronic Data Capture (REDCap) tools. Genetic matching for sex, age, hypertension, DM and hospital was performed in a 4:1 ratio.
Results
Of the 7,018 patients who had confirmed infection with SARS-CoV-2 in the registry, 31 patients with CD and 124 matched controls were included. Overall, the median age was 72 (64.-80) years-old and 44.5% were male. At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p<0.05 for both). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). Seventy-two (46.5%) patients required admission to the intensive care unit. In-hospital management, outcomes and complications were similar between the groups.
Conclusions
In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no …
学术搜索中的文章
I Molina, MS Marcolino, MC Pires, LEF Ramos… - medRxiv, 2021