作者
R Domingues, G Costa de Carvalho, LM da Silva Oliveira, E Futata Taniguchi, JM Zimbres, V Aoki, AJ da Silva Duarte, MN Sato
发表日期
2015/1/1
期刊
British Journal of Dermatology
卷号
172
期号
1
页码范围
48-55
出版商
Blackwell Publishing Ltd
简介
Background
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. Toll‐like receptors (TLRs) bind numerous exogenous and endogenous antigens by recognizing conserved pathogen‐associated molecular patterns (PAMPs) and have the ability to induce the production of proinflammatory cytokines. Therefore, alterations in innate immunity could explain the inflammation and T‐cell autoreactivity leading to the development of LP disease.
Objectives
To evaluate how the host innate immune response to PAMPs is affected by cutaneous LP, primarily by using TLR agonists to induce proinflammatory cytokine secretion from peripheral blood mononuclear cells (PBMCs).
Methods
PBMCs from patients with LP and healthy control (HC) individuals were stimulated with agonists of TLR2/TLR1 (pam3csk4), TLR3 [poly(I:C)‐RIG], TLR4 …
学术搜索中的文章
R Domingues, GC de Carvalho, LM da Silva Oliveira… - British Journal of Dermatology, 2015