作者
Thiago Ferreira de Souza, Thiago Quinaglia AC Silva, Felipe Osorio Costa, Ravi Shah, Tomas G Neilan, Lício Velloso, Wilson Nadruz, Fabricio Brenelli, Andrei Carvalho Sposito, Jose Roberto Matos-Souza, Fernando Cendes, Otávio Rizzi Coelho, Michael Jerosch-Herold, Otavio Rizzi Coelho-Filho
发表日期
2018/8/6
期刊
JACC: Cardiovascular Imaging
卷号
11
期号
8
页码范围
1045-1055
出版商
JACC: Cardiovascular Imaging
简介
Objectives
The goal of this study was to demonstrate that cardiac magnetic resonance could reveal anthracycline-induced early tissue remodeling and its relation to cardiac dysfunction and left ventricular (LV) atrophy.
Background
Serum biomarkers of cardiac dysfunction, although elevated after chemotherapy, lack specificity for the mechanism of myocardial tissue alterations.
Methods
A total of 27 women with breast cancer (mean age 51.8 ± 8.9 years, mean body mass index 26.9 ± 3.6 kg/m2), underwent cardiac magnetic resonance before and up to 3 times after anthracycline therapy. Cardiac magnetic resonance variables were LV ejection fraction, normalized T2-weighted signal intensity for myocardial edema, extracellular volume (ECV), LV cardiomyocyte mass, intracellular water lifetime (τic; a marker of cardiomyocyte size), and late gadolinium enhancement.
Results
At baseline, patients had a relatively low (10 …
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