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Purpose: Nurses and other healthcare providers continue to underuse interventions demonstrated to be effective at improving health outcomes. We propose in this article that if more evidence‐based practice is wanted, greater use must be made of qualitative inquiry to obtain practice‐based evidence derived from the experiences and practices of healthcare providers and the contexts of healthcare provision.

Approach: We present a framework for the use of qualitative methods to contribute to the following categories of practice‐based evidence: (a) practice‐based interventions and implementation strategies, (b) causal mechanisms, (c) approaches to adaptation, (d) how‐to guidance, (e) unanticipated effects, and (f) relevant contextual factors.

Conclusions: Qualitative inquiry has an essential role to play in incorporating more practice‐based evidence into the evidence base for nursing practice.

Clinical Relevance …