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Histone recognition by reader modules constitutes a major mechanism for epigenetic regulation (Jenuwein and Allis 2001). BAHD1 (bromo adjacent homology domain containing protein 1) is a vertebrate-specific nuclear protein (Fig. S1) involved in gene silencing by promoting heterochromatin formation. BAHD1 is characteristic with an N-terminal proline-rich region, a nuclear localization signal motif, and a C-terminal bromo adjacent homology (BAH) domain (Fig. 1 A). Previous study revealed that BAHD1 could act as a scaffold protein and tether diverse heterochromatinassociated factors including HP1, MBD1, SETDB1, HDAC5, and several transcriptional factors to trigger facultative heterochromatin formation (Bierne, Tham et al. 2009). Consistent with a “repressive” role, BAHD1 binds to CpG-rich P3 promoter region of IGF2 (insulin-like growth factor II) then represses IGF2 and IGF2 antisense transcription via the …