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Solid tumors are characterized by increased interstitial fluid pressure and enhanced solid stress, contributing to poor intra–tumoral penetration of nano drug carriers. This offsets the benefits of enhanced permeation and retention effect often attributed to these drug carriers. We have developed a novel cell based targeting approach using mesenchymal stem cells (MSCs) as cellular drug carriers. MSCs have been indicated in the tumor-targeted therapy owing to their selective ability to home to tumors. Our work is focused on non–genetic modification of MSCs by incorporating nanoparticles loaded with chemotherapeutics to create cellular drug depots capable of homing to tumors and releasing drugs over a sustained period of time. Nano–engineered MSCs were manufactured by incubating MSCs with 100µg/mL of paclitaxel loaded (18.5% w/w paclitaxel) PLGA nanoparticles for 4 hours at 37°C without affecting their …