作者
Linzhen Hu, Yu Zhang, Hucheng Zhu, Junjun Liu, Hua Li, Xiao-Nian Li, Weiguang Sun, Junfen Zeng, Yongbo Xue, Yonghui Zhang
发表日期
2016/5/6
期刊
Organic letters
卷号
18
期号
9
页码范围
2272-2275
出版商
American Chemical Society
简介
Seven filicinic acid–based meroterpenoids (1–7), possessing 6/6/11, 6/6/7/5, or 6/6/10 ring systems, were isolated from Hypericum japonicum. All of them have novel skeletons with the incorporation of sesquiterpenoid moieties to an acylated filicinic acid. Compounds 2a and 4 exhibited significant efficacy on anti-Epstein–Barr virus, with EC50 values of 0.57 and 0.49 μM, respectively. Furthermore, compounds 2a and 4 were well accommodated to the binding pocket of 2GV9 predicted by the molecular docking.
学术搜索中的文章
Filicinic acid based meroterpenoids with anti-Epstein–Barr virus activities from Hypericum japonicum
L Hu, Y Zhang, H Zhu, J Liu, H Li, XN Li, W Sun, J Zeng… - Organic letters, 2016