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A 27-old-year old man presented with a 2-week history of increasing lymphadenopathy in his groin and neck. He also had marked hepatosplenomegaly. His blood count showed a haemoglobin concentration of 161g/l, white cell count 37Æ1× 109/l and platelet count 45× 109/l. His blood film was leucoerythroblastic. A bone marrow aspirate (top) showed a marked increase of myeloid cells with eosinophilia. This was initially considered to be reactive to the process that was causing the adenopathy. He thus went on to have a lymph node biopsy (bottom left), which demonstrated a monotonous replacement of nodal architecture by T lymphoblasts consistent with a diagnosis of precursor-T lymphoblastic lymphoma. His bone marrow cytogenetics (bottom right) subsequently showed at (8: 13)(p11; q12) translocation. This is a rare abnormality, which was previously designated the 8p11 myeloproliferative syndrome (EMS …