作者
Albert C Yeh, Antiopi Varelias, Anupama Reddy, Sierra M Barone, Stuart D Olver, Kate Chilson, Lynn E Onstad, Kathleen S Ensbey, Andrea S Henden, Luke Samson, Carla A Jaeger, Timothy Bi, Kimberly B Dahlman, Tae Kon Kim, Ping Zhang, Mariapia A Degli-Esposti, Evan W Newell, Madan H Jagasia, Jonathan M Irish, Stephanie J Lee, Geoffrey R Hill
发表日期
2021/12/30
期刊
Blood, The Journal of the American Society of Hematology
卷号
138
期号
26
页码范围
2874-2885
出版商
American Society of Hematology
简介
Donor and recipient cytomegalovirus (CMV) serostatus correlate with transplant-related mortality that is associated with reduced survival following allogeneic stem cell transplant (SCT). Prior epidemiologic studies have suggested that CMV seronegative recipients (R–) receiving a CMV-seropositive graft (D+) experience inferior outcomes compared with other serostatus combinations, an observation that appears independent of viral reactivation. We therefore investigated the hypothesis that prior donor CMV exposure irreversibly modifies immunologic function after SCT. We identified a CD4+/CD57+/CD27– T-cell subset that was differentially expressed between D+ and D– transplants and validated results with 120 patient samples. This T-cell subset represents an average of 2.9% (D–/R–), 18% (D–/R+), 12% (D+/R–), and 19.6% (D+/R+) (P < .0001) of the total CD4+ T-cell compartment and stably persists for at …
学术搜索中的文章
AC Yeh, A Varelias, A Reddy, SM Barone, SD Olver… - Blood, The Journal of the American Society of …, 2021