作者
James A St. John, Jenny AK Ekberg, Samantha J Dando, Adrian CB Meedeniya, Rachel E Horton, Michael Batzloff, Suzzanne J Owen, Stephanie Holt, Ian R Peak, Glen C Ulett, Alan Mackay-Sim, Ifor R Beacham
发表日期
2014/5/1
期刊
MBio
卷号
5
期号
2
页码范围
10.1128/mbio. 00025-14
出版商
American Society for Microbiology
简介
Melioidosis is a potentially fatal disease that is endemic to tropical northern Australia and Southeast Asia, with a mortality rate of 14 to 50%. The bacterium Burkholderia pseudomallei is the causative agent which infects numerous parts of the human body, including the brain, which results in the neurological manifestation of melioidosis. The olfactory nerve constitutes a direct conduit from the nasal cavity into the brain, and we have previously reported that B. pseudomallei can colonize this nerve in mice. We have now investigated in detail the mechanism by which the bacteria penetrate the olfactory and trigeminal nerves within the nasal cavity and infect the brain. We found that the olfactory epithelium responded to intranasal B. pseudomallei infection by widespread crenellation followed by disintegration of the neuronal layer to expose the underlying basal layer, which the bacteria then colonized. With the loss of the …
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JA St. John, JAK Ekberg, SJ Dando, ACB Meedeniya… - MBio, 2014