作者
J Manuel Ortega-Legaspi, Alberto López-Avila, Ulises Coffeen, Rosendo del Angel, Francisco Pellicer
发表日期
2003/1/1
期刊
European Journal of Pain
卷号
7
期号
5
页码范围
425-429
出版商
No longer published by Elsevier
简介
The cingulate cortex plays a key role in the affective component related to pain perception. This structure receives cholinergic projections and also plays a role in memory processing. Therefore, we propose that the cholinergic system in the anterior cingulate cortex is involved in the nociceptive memory process. We used scopolamine (10 μg in 0.25 μl / saline ) microinjected into the anterior cingulate cortex, either before thermonociception followed by a sciatic denervation, between thermonociception and denervation or after both procedures (n=10 each). The vehicle group (saline solution 0.9%, n=14) was microinjected before thermonociception. Chronic nociception was measured by the autotomy score, which onset and incidence were also determined. Group scopolamine–thermonociception–denervation (STD) presented the lowest autotomy score as compared to vehicle and group thermonociception …
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JM Ortega-Legaspi, A López-Avila, U Coffeen… - European Journal of Pain, 2003