作者
Uma Kant Sharma, Ramesh Kumar, Ashutosh Gupta, Risha Ganguly, Amit Kumar Singh, Anil Kumar Ojha, Abhay Kumar Pandey
发表日期
2019/4/1
期刊
Food and Chemical Toxicology
卷号
126
页码范围
34-40
出版商
Pergamon
简介
Metanil yellow, an azo dye, is a non-permitted synthetic food colour used extensively in India and other developing countries as food additive. Present communication reports the toxic effects of metanil yellow on hepatic and kidney tissues and its amelioration by eugenol, vitamin E and vitamin C. Oral administration of metanil yellow in albino Wistar rats for 28 days caused elevation in serum enzymes (glutamate oxaloacetate transaminase, gluatamate pyruvate transaminase, alkaline phosphatase), and total bilirubin along with decline in albumin and total protein levels. At tissue level, activities of oxidative stress markers viz., superoxide dismutase, catalase and reduced glutathione in liver and kidney were reduced to about half while malondialdehyde level increased significantly under the influence of metanil yellow. Co-administration of eugenol/vitamin E/vitamin C in metanil yellow intoxicated rats exhibited …
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UK Sharma, R Kumar, A Gupta, R Ganguly, AK Singh… - Food and Chemical Toxicology, 2019