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To the Editors: Clozapine and amisulpride are second-generation antipsychotics and clozapine is an effective drug for the management of treatment-resistant schizophrenia (TRS). 1 Stuttering is defined as a disruption in the normal fluency and pattern of speech, repetition, and prolongation of sounds. Stuttering can be developmental, and on the basis of secondary etiologies, it could be neurogenic or psychogenic. 2 Stuttering can also occur as a rare side effect of antipsychotics. 2, 3 There are many case reports that have highlighted clozapine as a cause of stuttering. 3 We describe a case of TRS and comorbid obsessive-compulsive disorder (OCD), who developed orofacial twitching and stuttering with both clozapine and amisulpride while being concurrently on fluoxetine. The patient also had an episode of seizure with amisulpride. To the best of our knowledge, this is the first case from India exploring the …