作者
L Martinez-Gac, B Alvarez, Z Garcia, M Marques, M Arrizabalaga, AC Carrera
发表日期
2004/4/1
来源
Biochemical Society Transactions
卷号
32
期号
2
页码范围
360-361
出版商
Portland Press Ltd.
简介
Cell cycle progression is a tightly controlled process. To initiate cell division, mitogens trigger a number of early signals that promote the G0–G1 transition by inducing cell growth and the activation of G1 cyclins. Activation of cyclin E/cdk2 (cyclin-dependent kinase 2) at the end of G1 is then required to trigger DNA synthesis (S phase entry). Among the early signals induced by mitogens, activation of PI3K (phosphoinositide 3-kinase) appears essential to induce cell cycle entry, as it regulates cell growth signalling pathways, which in turn determine the rate of cell cycle progression. Another mechanisms by which PI3K and its downstream effector protein kinase B regulate cell cycle entry is by inactivation of the FOXO (Forkhead Box, subgroup O) transcription factors, which induce expression of quiescence genes such as those encoding p27kip, p130 and cyclin G2. PI3K/FOXO then work as a complementary switch …
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L Martinez-Gac, B Alvarez, Z Garcia, M Marques… - Biochemical Society Transactions, 2004