作者
Anna Kazanets, Tatiana Shorstova, Khalid Hilmi, Maud Marques, Michael Witcher
发表日期
2016/4/1
来源
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer
卷号
1865
期号
2
页码范围
275-288
出版商
Elsevier
简介
Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However, there are a number of universal aberrations common to all cancers, one of these being the epigenetic silencing of tumor suppressor genes (TSGs). The silencing of TSGs is thought to be an early, driving event in the oncogenic process. With this in consideration, great efforts have been made to develop small molecules aimed at the restoration of TSGs in order to limit tumor cell proliferation and survival. However, the molecular forces that drive the broad epigenetic reprogramming and transcriptional repression of these genes remain ill-defined. Undoubtedly, understanding the molecular underpinnings of transcriptionally silenced TSGs will aid us in our ability to reactivate these key anti-cancer targets. Here, we describe what we consider to be the five most logical molecular mechanisms that may account for this widely …
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A Kazanets, T Shorstova, K Hilmi, M Marques… - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2016