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A central nosological problem concerns the etiological relationship of emotional dysregulation with ADHD. Molecular genetic risk scores provide a novel method for informing this question.

Participants were 514 community‐recruited children of Northern European descent age 7‐11 defined as ADHD or non‐ADHD by detailed research evaluation. Parents‐rated ADHD on standardized ratings and child temperament on the Temperament in Middle Childhood Questionnaire (TMCQ) and reported on ADHD and comorbid disorders by semi‐structured clinical interview. Categorical and dimensional variables were created for ADHD, emotional dysregulation (implicating disruption of regulation of both anger‐irritability and of positive valence surgency‐sensation seeking), and irritability alone (anger dysregulation). Genome‐wide polygenic risk scores (PRS) were computed for ADHD and depression …