作者
Marcia Irene Canto, Ralph H Hruban, Elliot K Fishman, Ihab R Kamel, Richard Schulick, Zhe Zhang, Mark Topazian, Naoki Takahashi, Joel Fletcher, Gloria Petersen, Alison P Klein, Jennifer Axilbund, Constance Griffin, Sapna Syngal, John R Saltzman, Koenraad J Mortele, Jeffrey Lee, Eric Tamm, Raghunandan Vikram, Priya Bhosale, Daniel Margolis, James Farrell, Michael Goggins, American Cancer of the Pancreas Screening (CAPS) Consortium
发表日期
2012/4/1
期刊
Gastroenterology
卷号
142
期号
4
页码范围
796-804
出版商
WB Saunders
简介
BACKGROUND & AIMS
The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germline mutation. Screening can detect curable, noninvasive pancreatic neoplasms, but the optimal imaging approach is not known. We determined the baseline prevalence and characteristics of pancreatic abnormalities using 3 imaging tests to screen asymptomatic, high-risk individuals (HRIs).
METHODS
We screened 225 asymptomatic adult HRIs at 5 academic US medical centers once, using computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasonography (EUS). We compared results in a blinded, independent fashion.
RESULTS
Ninety-two of 216 HRIs (42%) were found to have at least 1 pancreatic mass (84 cystic, 3 solid) or a dilated pancreatic duct (n = 5) by any of the imaging modalities. Fifty-one of the 84 HRIs with a cyst (60.7 …
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MI Canto, RH Hruban, EK Fishman, IR Kamel… - Gastroenterology, 2012