作者
Juhua Luo, Motoki Iwasaki, Manami Inoue, Shizuka Sasazuki, Tetsuya Otani, Weimin Ye, Shoichiro Tsugane
发表日期
2007/8
期刊
Cancer Causes & Control
卷号
18
期号
6
页码范围
603-612
出版商
Kluwer Academic Publishers
简介
Objective
The effects of BMI and physical activity on the risk of pancreatic cancer were investigated in a large population-based cohort study in Japan (JPHC study). In particular, we explored how these effects were influenced by smoking status and a history of diabetes.
Methods
In total, 99,670 participants (47,499 men, and 52,171women) were followed for an average of 11 years through the end of 2003. Hazard ratios (HR) and their 95% confidence intervals (CI) were estimated by Cox proportional hazards models.
Results
A total of 224 incident cases (128 men, 96 women) of pancreatic cancer were identified. A statistically significant excess risk of pancreatic cancer was associated with current smoking (HR = 1.8, CI 1.1–3.0) and a history of diabetes (HR = 2.1, CI 1.3–3.5) among men. A similar increase in risk …
引用总数
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J Luo, M Iwasaki, M Inoue, S Sasazuki, T Otani, W Ye… - Cancer Causes & Control, 2007