作者
Neil M Iyengar, Rhonda Arthur, JoAnn E Manson, Rowan T Chlebowski, Candyce H Kroenke, Lindsay Peterson, Ting-Yuan D Cheng, Elizabeth C Feliciano, Dorothy Lane, Juhua Luo, Rami Nassir, Kathy Pan, Sylvia Wassertheil-Smoller, Victor Kamensky, Thomas E Rohan, Andrew J Dannenberg
发表日期
2019/2/1
期刊
JAMA oncology
卷号
5
期号
2
页码范围
155-163
出版商
American Medical Association
简介
Importance
Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)–positive subtype in postmenopausal women. Whether excess adiposity is associated with increased risk in women with a normal body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is unknown.
Objective
To investigate the association between body fat and breast cancer risk in women with normal BMI.
Design, Setting, and Participants
This ad hoc secondary analysis of the Women’s Health Initiative (WHI) clinical trial and observational study cohorts was restricted to postmenopausal participants with a BMI ranging from 18.5 to 24.9. Women aged 50 to 79 years were enrolled from October 1, 1993, through December 31, 1998. Of these, 3460 participants underwent body fat measurement with dual-energy x-ray absorptiometry (DXA) at 3 US designated centers with …
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NM Iyengar, R Arthur, JAE Manson, RT Chlebowski… - JAMA oncology, 2019