作者
Peter Pao-Huang, Bowen Jing, Bonnie Berger
发表日期
2023
研讨会论文
NeurIPS 2023 AI for Science Workshop
简介
Accurate protein complex structure modeling is a necessary step in understanding the behavior of biological pathways and cellular systems. While some works have attempted to address this challenge, there is still a need for scaling existing methods to larger protein complexes. To address this need, we propose a novel diffusion generative model (DGM) that predicts large multimeric protein structures by learning to rigidly dock its chains together. Additionally, we construct a new dataset specifically for large protein complexes used to train and evaluate our DGM. We substantially improve prediction runtime and completion rates while maintaining competitive accuracy with current methods.
引用总数
学术搜索中的文章
P Pao-Huang, B Jing, B Berger - NeurIPS 2023 AI for Science Workshop, 2023