作者
Madhav Thambisetty, Andrew Simmons, Latha Velayudhan, Abdul Hye, James Campbell, Yi Zhang, Lars-Olof Wahlund, Eric Westman, Anna Kinsey, Andreas Güntert, Petroula Proitsi, John Powell, Mirsada Causevic, Richard Killick, Katie Lunnon, Steven Lynham, Martin Broadstock, Fahd Choudhry, David R Howlett, Robert J Williams, Sally I Sharp, Cathy Mitchelmore, Catherine Tunnard, Rufina Leung, Catherine Foy, Darragh O’Brien, Gerome Breen, Simon J Furney, Malcolm Ward, Iwona Kloszewska, Patrizia Mecocci, Hilkka Soininen, Magda Tsolaki, Bruno Vellas, Angela Hodges, Declan GM Murphy, Sue Parkins, Jill C Richardson, Susan M Resnick, Luigi Ferrucci, Dean F Wong, Yun Zhou, Sebastian Muehlboeck, Alan Evans, Paul T Francis, Christian Spenger, Simon Lovestone
发表日期
2010/7/1
期刊
Archives of general psychiatry
卷号
67
期号
7
页码范围
739-748
出版商
American Medical Association
简介
Context
Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD).
Objective
To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach.
Design
Discovery-phase proteomics to identify plasma proteins associated with correlates of AD pathology. Confirmation and validation using immunodetection in a replication set and an animal model.
Setting
A multicenter European study (AddNeuroMed) and the Baltimore Longitudinal Study of Aging.
Participants
Patients with AD, subjects with mild cognitive impairment, and healthy controls with standardized clinical assessments and structural neuroimaging.
Main Outcome Measures
Association of plasma proteins with brain atrophy, disease severity, and rate of clinical progression. Extension studies in humans and transgenic mice tested the association between plasma proteins and brain …
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M Thambisetty, A Simmons, L Velayudhan, A Hye… - Archives of general psychiatry, 2010