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Purpose The purpose of this study was to assess the effect that changes in sex hormone levels have on intraocular pressure (IOP) in menopausal women.

Subjects and Methods Thirty menopausal women on hormone replacement therapy and 32 menopausal women who had never received hormone replacement therapy (HRT), matched for age and duration of amenorrhea, participated in this study. Intraocular pressures were measured with Goldmann applanation tonometer. Serum levels were measured for estradiol, free testosterone, and follicle stimulating hormone (FSH). The influence of serum hormone levels on IOP was assessed by correlation analysis.

Results The mean IOP of postmenopausal women receiving HRT (13.29±2.28 mm Hg) was not significantly different from that of menopausal women not receiving HRT (13.56±2.5 mm Hg, P= 0.24). Higher testosterone levels were associated with higher IOPs …