作者
Jeong Seok Hwa, Yong Chun Jin, Young Soo Lee, Young Shin Ko, Young Min Kim, Lian Yu Shi, Hye Jung Kim, Jae Heun Lee, Tran Minh Ngoc, Ki Hwan Bae, Yeong Shik Kim, Ki Churl Chang
发表日期
2012/1/31
期刊
Journal of ethnopharmacology
卷号
139
期号
2
页码范围
605-615
出版商
Elsevier
简介
ETHNOPHARMACOLOGICAL RELEVANCE
Cinnamomum cassia Blume has been used as a traditional Chinese herbal medicine for alleviation of fever, inflammation, chronic bronchitis, and to improve blood circulation.
AIM OF THE STUDY
We addressed whether 2-methoxycinnamaldehyde (2-MCA), one of active ingredients of Cinnamomum cassia, reduces vascular cell adhesion molecule-1 (VCAM-1) expression in tumor necrosis factor-alpha (TNF-α)-activated endothelial cells and protects ischemia/reperfusion (I/R)-injury due to heme oxygenase (HO)-1 induction.
MATERIALS AND METHODS
Adult male rats were subjected to 30min of ischemia by occlusion of the left anterior descending coronary artery followed by 24h of reperfusion. Rats were randomized to receive vehicle or 2-MCA (i.v.) 10min before reperfusion.
RESULTS
Administration of 2-MCA significantly improved I/R-induced myocardial dysfunction …
学术搜索中的文章
JS Hwa, YC Jin, YS Lee, YS Ko, YM Kim, LY Shi… - Journal of ethnopharmacology, 2012
