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While activation of cannabinoid (CB2) receptors has been shown to be neuroprotective, no studies have examined whether this neuroprotection is directed at cerebral arterioles and no studies have examined whether activation of CB2 receptors can rescue cerebrovascular dysfunction during a chronic disease states such as type 1 diabetes (T1D). Our goal was to test that hypothesis that administration of a CB2 agonist (JWH‐133) would improve impaired endothelial (eNOS)‐ and neuronal (nNOS)‐ dependent dilation of cerebral arterioles during T1D. In vivo diameter of cerebral arterioles in nondiabetic and diabetic rats was measured in response to an eNOS‐dependent agonist (adenosine 5′‐diphosphate; ADP), an nNOS‐dependent agonist (N‐methyl‐D‐aspartate; NMDA), and an NOS‐independent agonist (nitroglycerin) before and following JWH‐133 (1 mg/kg IP). Dilation of cerebral arterioles to ADP and …