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Aydin Tay, William G Mayhan, Denise Arrick, Chun-Hong Shao, Hong Sun, Keshore R Bidasee

Wednesday, March 4, 2009 Page 1 to wildtype animals. Upon induction of hyperglycemia in knockouts, expression of PKC d was only slightly increased to the level found in non-diabetic wildtypes. Expression, phosphorylation and translocation of PKC isoforms, however, remained unaffected by the induction of diabetes in Ga11-deficient mice. We conclude that Ga11 is central to the induction of myocardial hypertrophy in type 1 diabetes. Activation of PKC a and z appear to be important pathways in hypertrophic signaling via Ga11. The inhibition of this pathway may in part explain the strong therapeutic benefit of AT1 receptor blockade in diabetic patients. 3518-Pos Board B565 Methylglyoxal Impairs Brain Microvascular Endothelial Cell Function In Vivo and In Vitro Aydin Tay1,*, William G. Mayhan2,*, Denise Arrick2, Chun-Hong Shao1, Hong Sun2, Keshore R. Bidasee1. 1University of Nebraska Medical Center, …