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25 Decreased dilation of cerebral arterioles via an increase in oxidative stress may be a 26 contributing factor in the pathogenesis of diabetes-induced complications leading to cognitive 27 dysfunction and/or stroke. Our goal was to determine whether resveratrol, a polyphenolic 28 compound present in red wine, has a protective effect on cerebral arterioles during Type 1 29 diabetes (T1D). We measured responses of cerebral arterioles in untreated and resveratrol-30 treated (10 mg/kg/day) nondiabetic and diabetic rats to eNOS-and nNOS-dependent agonists, 31 and a NOS-independent agonist. In addition, we harvested brain tissue from nondiabetic and 32 diabetic rats to measure levels of superoxide under basal conditions. Further, we used Western 33 blot analysis to determine protein expression of eNOS, nNOS, SOD-1 and SOD-2 in cerebral 34 arterioles and/or brain tissue from untreated and resveratrol …