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Suboptimal peak inspiratory flow rate (PIFR) is highly prevalent in chronic obstructive pulmonary disease (COPD) patients owing to the mismatch of their own PIFR with the corresponding inhaler‐device resistance. This study aimed to evaluate aerosol drug‐delivery and short‐term clinical outcomes of suboptimal PIFR in COPD subjects.

Twenty optimal and suboptimal COPD subjects were crossed over in this prospective, randomised, controlled, open‐label study. They were tested for urinary salbutamol amount (USAL30) and spirometric response 30 min poststudy dose (200 µg salbutamol) through Aerolizer^® and Handihaler^® after assessment of their own PIFR through In‐Check™ Dial G16. Urine samples were extracted through solid‐phase extraction and assayed through a high performance liquid chromatography (HPLC) method.

Mean USAL30 was significantly higher in the …