作者
Michael Y Shapira, Igor B Resnick, Sunwen Chou, Avidan U Neumann, Nell S Lurain, Thomas Stamminger, Orit Caplan, Niveen Saleh, Thomas Efferth, Manfred Marschall, Dana G Wolf
发表日期
2008/5/1
期刊
Clinical Infectious Diseases
卷号
46
期号
9
页码范围
1455-1457
出版商
The University of Chicago Press
简介
This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation. Artesunate treatment resulted in a 1.7–2.1-log reduction in viral load by treatment day 7, with a viral half-life of 0.9–1.9 days, indicating a highly effective block in viral replication.
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MY Shapira, IB Resnick, S Chou, AU Neumann… - Clinical Infectious Diseases, 2008