作者
Eloa Rodrigues Luvizuto, Thallita Pereira Queiroz, Sheila Mônica Damásio Dias, Tetuo Okamoto, Rita Cássia Menegati Dornelles, Idelmo Rangel Garcia Jr, Roberta Okamoto
发表日期
2010/1/1
期刊
Archives of oral biology
卷号
55
期号
1
页码范围
52-59
出版商
Pergamon
简介
OBJECTIVE
To investigate the effects of bone-resorption inhibitors (oestrogen and raloxifene) on the RANKL/OPG balance during the chronology of the alveolar healing process in ovariectomized (OVX) rats by means of immunocolocalization and histomorphometric analysis.
MATERIALS AND METHODS
One hundred sixty female Wistar rats at 70 days of age were either OVX or sham-operated and divided into four groups: sham, OVX/Oil, OVX with E2 replacement (17β-estradiol, 400μg/month), OVX with RLX treatment (1mg/kg bw/day). The 60-day treatment started 8 days after ovariectomy. The incisors were extracted to allow analysis of 7, 14, 21, 28 and 42 days of wound healing. After obtaining the histological samples, slides were stained with hematoxylin and eosin or subjected to immunocolocalization reaction for RANKL and OPG. Results were quantitatively evaluated.
RESULTS
Histomorphometric analysis …
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ER Luvizuto, TP Queiroz, SMD Dias, T Okamoto… - Archives of oral biology, 2010