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Compounds with 11H-indeno [1, 2-b] quinoxalin-11-one scaffold–IQ–1 and IQ–1E (Fig. 1) were recently identified and characterized as potent C-Jun N-terminal kinase (JNK) inhibitors [1]. JNKs play important role in the pathogenesis of numerous diseases including rheumatoid arthritis, insulin resistance, cancer, Alzheimer's, and Parkinson's diseases [2, 3]. In particular, they regulate pro-inflammatory cytokine secretion and signaling cascades that lead to inflammation and disfunction [4]. Therefore, JNKs are attractive targets for the treatment of cytokine driven diseases.

However, poor solubility in water and organic solvents affects bioavailability of IQ–1 and IQ–1E and limits their application. In order to solve this issue, we fabricated poly (ε-caprolactone)-based scaffolds doped with IQ–1 (PCL-IQ-1) and IQ–1E (PCL-IQ-1E) via electrospinning using 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol as a common solvent [5].