作者
Tao Zuo, Qin Liu, Fen Zhang, Yun Kit Yeoh, Yating Wan, Hui Zhan, Grace CY Lui, Zigui Chen, Amy YL Li, Chun Pan Cheung, Nan Chen, Wenqi Lv, Rita WY Ng, Eugene YK Tso, Kitty SC Fung, Veronica Chan, Lowell Ling, Gavin Joynt, David SC Hui, Francis KL Chan, Paul KS Chan, Siew C Ng
发表日期
2021/12
期刊
Microbiome
卷号
9
页码范围
1-16
出版商
BioMed Central
简介
Background
Coronavirus disease 2019 (COVID-19) caused by the enveloped RNA virus SARS-CoV-2 primarily affects the respiratory and gastrointestinal tracts. SARS-CoV-2 was isolated from fecal samples, and active viral replication was reported in human intestinal cells. The human gut also harbors an enormous amount of resident viruses (collectively known as the virome) that play a role in regulating host immunity and disease pathophysiology. Understanding gut virome perturbation that underlies SARS-CoV-2 infection and severity is an unmet need.
Methods
We enrolled 98 COVID-19 patients with varying disease severity (3 asymptomatic, 53 mild, 34 moderate, 5 severe, 3 critical) and 78 non-COVID-19 controls matched for gender and co-morbidities. All subjects had fecal specimens sampled at inclusion. Blood specimens were collected for …
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