作者
Yun Kit Yeoh, Tao Zuo, Grace Chung-Yan Lui, Fen Zhang, Qin Liu, Amy YL Li, Arthur CK Chung, Chun Pan Cheung, Eugene YK Tso, Kitty SC Fung, Veronica Chan, Lowell Ling, Gavin Joynt, David Shu-Cheong Hui, Kai Ming Chow, Susanna So Shan Ng, Timothy Chun-Man Li, Rita WY Ng, Terry CF Yip, Grace Lai-Hung Wong, Francis KL Chan, Chun Kwok Wong, Paul KS Chan, Siew C Ng
发表日期
2021/4/1
期刊
Gut
卷号
70
期号
4
页码范围
698-706
出版商
BMJ Publishing Group
简介
Objective
Although COVID-19 is primarily a respiratory illness, there is mounting evidence suggesting that the GI tract is involved in this disease. We investigated whether the gut microbiome is linked to disease severity in patients with COVID-19, and whether perturbations in microbiome composition, if any, resolve with clearance of the SARS-CoV-2 virus.
Methods
In this two-hospital cohort study, we obtained blood, stool and patient records from 100 patients with laboratory-confirmed SARS-CoV-2 infection. Serial stool samples were collected from 27 of the 100 patients up to 30 days after clearance of SARS-CoV-2. Gut microbiome compositions were characterised by shotgun sequencing total DNA extracted from stools. Concentrations of inflammatory cytokines and blood markers were measured from plasma.
Results
Gut microbiome composition was significantly altered in patients with COVID-19 compared with …
学术搜索中的文章
YK Yeoh, T Zuo, GCY Lui, F Zhang, Q Liu, AYL Li… - Gut, 2021