作者
Rik Ossenkoppele, Willemijn J Jansen, Gil D Rabinovici, Dirk L Knol, Wiesje M van der Flier, Bart NM van Berckel, Philip Scheltens, Pieter Jelle Visser, Sander CJ Verfaillie, Marissa D Zwan, Sofie M Adriaanse, Adriaan A Lammertsma, Frederik Barkhof, William J Jagust, Bruce L Miller, Howard J Rosen, Susan M Landau, Victor L Villemagne, Christopher C Rowe, Dong Y Lee, Duk L Na, Sang W Seo, Marie Sarazin, Catherine M Roe, Osama Sabri, Henryk Barthel, Norman Koglin, John Hodges, Cristian E Leyton, Rik Vandenberghe, Koen Van Laere, Alexander Drzezga, Stefan Forster, Timo Grimmer, Pascual Sánchez-Juan, Jose M Carril, Vincent Mok, Vincent Camus, William E Klunk, Ann D Cohen, Philipp T Meyer, Sabine Hellwig, Andrew Newberg, Kristian S Frederiksen, Adam S Fleisher, Mark A Mintun, David A Wolk, Agneta Nordberg, Juha O Rinne, Gaël Chételat, Alberto Lleo, Rafael Blesa, Juan Fortea, Karine Madsen, Karen M Rodrigue, David J Brooks, Amyloid PET Study Group
发表日期
2015/5/19
期刊
Jama
卷号
313
期号
19
页码范围
1939-1950
出版商
American Medical Association
简介
Importance
Amyloid-β positron emission tomography (PET) imaging allows in vivo detection of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its diagnostic utility is still unclear because amyloid plaques also occur in patients with non–AD dementia.
Objective
To use individual participant data meta-analysis to estimate the prevalence of amyloid positivity on PET in a wide variety of dementia syndromes.
Data Sources
The MEDLINE and Web of Science databases were searched from January 2004 to April 2015 for amyloid PET studies.
Study Selection
Case reports and studies on neurological or psychiatric diseases other than dementia were excluded. Corresponding authors of eligible cohorts were invited to provide individual participant data.
Data Extraction and Synthesis
Data were provided for 1359 participants with clinically diagnosed AD and 538 participants with non–AD dementia …
学术搜索中的文章
R Ossenkoppele, WJ Jansen, GD Rabinovici, DL Knol… - Jama, 2015