作者
Pieter Jelle Visser, Frans Verhey, Dirk L Knol, Philip Scheltens, Lars-Olof Wahlund, Yvonne Freund-Levi, Magda Tsolaki, Lennart Minthon, Åsa K Wallin, Harald Hampel, Katharina Bürger, Tuula Pirttila, Hilkka Soininen, Marcel Olde Rikkert, Marcel M Verbeek, Luiza Spiru, Kaj Blennow
发表日期
2009/7/1
期刊
The Lancet Neurology
卷号
8
期号
7
页码范围
619-627
出版商
Elsevier
简介
Background
Alzheimer's disease (AD) pathology is common in patients with amnestic mild cognitive impairment (aMCI) without dementia, but the prevalence of AD pathology in patients with subjective cognitive impairment (SCI) and non-amnestic mild cognitive impairment (naMCI) is unknown. AD is characterised by decreased CSF concentrations of Aβ42 and increased concentrations of tau. We investigated the prevalence of a CSF AD profile in patients with SCI, naMCI, or aMCI and the association of this profile with cognitive outcome in each group.
Methods
Patients with SCI, naMCI, aMCI, and neurologically healthy controls were recruited from 20 memory clinics across Europe, between January, 2003, and June, 2005, into this prospective cohort study. A CSF AD profile was defined as an abnormal ratio of Aβ42:tau. Patients were assessed annually up to 3 years. Outcome measures were changes in memory …
引用总数
学术搜索中的文章
PJ Visser, F Verhey, DL Knol, P Scheltens… - The Lancet Neurology, 2009