作者
Claire Bridel, Wessel N Van Wieringen, Henrik Zetterberg, Betty M Tijms, Charlotte E Teunissen, José C Alvarez-Cermeño, Ulf Andreasson, Markus Axelsson, David C Bäckström, Ales Bartos, Maria Bjerke, Kaj Blennow, Adam Boxer, Lou Brundin, Joachim Burman, Tove Christensen, Lenká Fialová, Lars Forsgren, Jette L Frederiksen, Magnus Gisslén, Elizabeth Gray, Martin Gunnarsson, Sara Hall, Oskar Hansson, Megan K Herbert, Joel Jakobsson, Jan Jessen-Krut, Shorena Janelidze, Gudmundur Johannsson, Michael Jonsson, Ludwig Kappos, Mohsen Khademi, Michael Khalil, Jens Kuhle, Mikael Landén, Ville Leinonen, Giancarlo Logroscino, Ching-Hua Lu, Jan Lycke, Nadia K Magdalinou, Andrea Malaspina, Niklas Mattsson, Lieke H Meeter, Sanjay R Mehta, Signe Modvig, Tomas Olsson, Ross W Paterson, Josué Pérez-Santiago, Fredrik Piehl, Yolande AL Pijnenburg, Okko T Pyykkö, Oskar Ragnarsson, Julio C Rojas, Jeppe Romme Christensen, Linda Sandberg, Carole S Scherling, Jonathan M Schott, Finn T Sellebjerg, Isabella L Simone, Tobias Skillbäck, Morten Stilund, Peter Sundström, Anders Svenningsson, Rosanna Tortelli, Carla Tortorella, Alessandro Trentini, Maria Troiano, Martin R Turner, John C van Swieten, Mattias Vågberg, Marcel M Verbeek, Luisa M Villar, Pieter Jelle Visser, Anders Wallin, Andreas Weiss, Carsten Wikkelsø, Edward J Wild, NFL Group
发表日期
2019/9/1
来源
JAMA neurology
卷号
76
期号
9
页码范围
1035-1048
出版商
American Medical Association
简介
Importance
Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date.
Objectives
To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating clinically similar conditions.
Data Sources
PubMed was searched for studies published between January 1, 2006, and January 1, 2016, reporting cNfL levels (using the search termsneurofilament lightandcerebrospinal fluid) in neurological or psychiatric conditions and/or in HC.
Study Selection
Studies reporting NfL levels measured in lumbar CSF using a commercially available immunoassay, as well as age and sex.
Data Extraction …
学术搜索中的文章
C Bridel, WN Van Wieringen, H Zetterberg, BM Tijms… - JAMA neurology, 2019