作者
Niklas Mattsson, Henrik Zetterberg, Oskar Hansson, Niels Andreasen, Lucilla Parnetti, Michael Jonsson, Sanna-Kaisa Herukka, Wiesje M van der Flier, Marinus A Blankenstein, Michael Ewers, Kenneth Rich, Elmar Kaiser, Marcel Verbeek, Magda Tsolaki, Ezra Mulugeta, Erik RosÚn, Dag Aarsland, Pieter Jelle Visser, Johannes Schr, Jan Marcusson, Mony de Leon, Harald Hampel, Philip Scheltens, Tuula Pirttilń, Anders Wallin, Maria Eriksdotter, Lennart Minthon, Bengt Winblad, Kaj Blennow
发表日期
2009/7/22
期刊
Jama
卷号
302
期号
4
页码范围
385-393
出版商
American Medical Association
简介
Context
Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted.
Objective
To determine the diagnostic accuracy of CSF β-amyloid1-42 (Aβ42), total tau protein (T-tau), and tau phosphorylated at position threonine 181 (P-tau) for predicting incipient AD in patients with MCI.
Design, Setting, and Participants
The study had 2 parts: a cross-sectional study involving patients with AD and controls to identify cut points, followed by a prospective cohort study involving patients with MCI, conducted 1990-2007. A total of 750 individuals with MCI, 529 with AD, and 304 controls were recruited by 12 centers in Europe and the United States. Individuals with MCI were followed up for at least 2 years or until symptoms had progressed to …
引用总数
学术搜索中的文章
N Mattsson, H Zetterberg, O Hansson, N Andreasen… - Jama, 2009