作者
Chang Liu, Devinder Dhindsa, Zakaria Almuwaqqat, Yi-An Ko, Anurag Mehta, Ayman A Alkhoder, Zahran Alras, Shivang Rajan Desai, Krishan Jignesh Patel, Ananya Hooda, Mohamad Wehbe, Laurence S Sperling, Yan V Sun, Arshed A Quyyumi
发表日期
2022/7/1
期刊
JAMA cardiology
卷号
7
期号
7
页码范围
672-680
出版商
American Medical Association
简介
Importance
Previous studies have shown lower cardiovascular risk with higher high-density lipoprotein cholesterol (HDL-C) levels. However, recent data in the general population have shown increased risk of adverse outcomes at very high HDL-C concentrations.
Objective
To study the association between very high HDL-C levels (>80 mg/dL) and mortality in patients with coronary artery disease (CAD) and to investigate the association of known HDL-C genotypes with high HDL-C level outcomes.
Design, Setting, and Participants
This prospective, multicenter, cohort study, conducted from 2006 to present in the UK and from 2003 to present in Atlanta, Georgia, recruited patients with CAD from the UK Biobank (UKB) and the Emory Cardiovascular Biobank (EmCAB), respectively. Patients without confirmed CAD were excluded from the study. Data analyses were conducted from May 10, 2020, to April 28, 2021.
Exposure …
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C Liu, D Dhindsa, Z Almuwaqqat, YA Ko, A Mehta… - JAMA cardiology, 2022