作者
Alexander C Razavi, Leslee J Shaw, Daniel S Berman, Matthew J Budoff, Nathan D Wong, Viola Vaccarino, Marly van Assen, Carlo N De Cecco, Arshed A Quyyumi, Anurag Mehta, Paul Muntner, Michael D Miedema, Alan Rozanski, John A Rumberger, Khurram Nasir, Roger S Blumenthal, Laurence S Sperling, Martin Bødtker Mortensen, Seamus P Whelton, Michael J Blaha, Omar Dzaye
发表日期
2024/2/21
期刊
JACC: Cardiovascular Imaging
出版商
Elsevier
简介
Background
Although a coronary artery calcium (CAC) of ≥1,000 is a subclinical atherosclerosis threshold to consider combination lipid-lowering therapy, differentiating very high from high atherosclerotic cardiovascular disease (ASCVD) risk in this patient population is not well-defined.
Objectives
Among persons with a CAC of ≥1,000, the authors sought to identify risk factors equating with very high-risk ASCVD mortality rates.
Methods
The authors studied 2,246 asymptomatic patients with a CAC of ≥1,000 from the CAC Consortium without a prior ASCVD event. Cox proportional hazards regression modelling was performed for ASCVD mortality during a median follow-up of 11.3 years. Crude ASCVD mortality rates were compared with those reported for secondary prevention trial patients classified as very high risk, defined by ≥2 major ASCVD events or 1 major event and ≥2 high-risk conditions (1.4 per 100 …
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AC Razavi, LJ Shaw, DS Berman, MJ Budoff, ND Wong… - JACC: Cardiovascular Imaging, 2024