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Introduction: Although SSRIs are no longer widely prescribed for post-stroke motor recovery, fluoxetine demonstrated beneficial effects on post-stroke depression (PSD). Given potential side effects of SSRIs, targeted initiation among individuals at highest risk for PSD warrants consideration. While previous studies have identified stroke severity and psychiatric history as factors associated with PSD, the predictability of PSD remains unknown. The purpose of this study is to investigate inpatient predictive factors to better identify individuals who might derive the most benefit from targeted initiation of SSRIs.

Methods: All adult patients presenting to our tertiary academic stroke center with acute ischemic stroke between 2016-2020 were enrolled in a prospectively-collected stroke registry. Patients were seen 4-6 weeks post-discharge and a subset were administered the PHQ-9 (Patient Health Questionnaire-9) to screen …