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Wettability is an important factor controlling the displacement of immiscible fluids in porous media and therefore affects the flow and transport of supercritical (sc) CO₂ in geologic carbon sequestration. Because few studies have focused on the wettability effect in scCO₂-brine flow systems, we experimentally and numerically tested influences of wettability on drainage at the pore network scale. Using a high-pressure micromodel-microscopy system, we performed experiments of scCO₂ invasion into brine-saturated water-wet and intermediate-wet micromodels, and recorded the scCO₂ invasion morphology under reservoir relevant conditions. We also performed pore-scale numerical simulations to infer 3D details of fluid–fluid displacement processes. During drainage under intermediate-wet conditions, we found higher scCO₂ saturation, wider scCO₂ fingering, and more compact displacement patterns. The …